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Ingredient intelligence

Avenanthramides (colloidal oat)

Botanical · Avena Sativa (Oat) Kernel Extract · formula unavailable

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Avenanthramides are a family of phenolic alkaloids characteristic of oats. Extracts are mixtures, so composition varies between materials and single-molecule identity data are limited.

Single human studyOne curated human study — the finding has not been independently repeated in this dataset.

Molecular identity

Structure image unavailable

Formula
Data unavailable
Molecular weight
Data unavailable
PubChem CID
Data unavailable
ChEBI
Data unavailable

Biological targets

  • Transcription factor RelA (NF-kappa-B p65)

    low confidence

    inhibits · structural protein

    Reduced NF-kB-driven reporter activity reported in keratinocyte models.

    UniProt Q04206

  • Histamine H1 receptor (HRH1)

    low confidence

    modulates · receptor

    Anti-itch endpoints reported; receptor-level mechanism not established.

    UniProt P35367

Molecules & genes

Molecules

  • Avenanthramide C (representative)formula unavailable

Genes / proteins

How could this ingredient interact with biology?

Biological network

Ingredient → molecule → target → gene/protein → pathway → process → studied outcome. Relationship strength is drawn from the curated confidence tier; nothing is added to make the chain look complete.

100%
Avenanthramides (colloida…Avenanthramide C (represe…Stratum corneum hydrationStudied for itch and irri…

drag to pan · hover to isolate a path · click a node for detail

IngredientMoleculeTargetGenePathwayProcessOutcome

7 lower-confidence relationships are hidden at this filter level. Use “Show more biology” to include them.

Text alternative for this network
  • Avenanthramides (colloidal oat) is molecule Avenanthramide C (representative) — high confidence
  • Stratum corneum hydration studied in Studied for itch and irritation endpoints in dry, sensitive skin — medium confidence

Biological pathways

Cutaneous inflammatory cytokine signalling

low confidence

Reduced pro-inflammatory cytokine release reported in cell models of irritated skin.

Literature

Evidence engine

Limited

Mostly mechanistic, animal or single-study evidence.

Skinceptor Evidence Index

40

experimental · of 100

This index is a research-navigation aid describing how much evidence exists and how it was produced. It is not a medical safety score, an efficacy guarantee, or a clinical recommendation.

Study composition

  • Human1
  • In-vitro1
  • Review1
Total studies
3
Human studies
1
Largest sample
27
Range
2005–2010

Index breakdown

  • Study design quality47% × 28%

    Mean design weight across curated studies (meta-analysis 1.0, RCT 0.9, other human 0.7, review 0.45, animal 0.35, in-vitro 0.25).

  • Human evidence share33% × 22%

    Proportion of curated evidence measured in people rather than cells or animals.

  • Evidence volume63% × 14%

    Log-scaled count of curated studies, so volume alone cannot dominate the score.

  • Largest sample size48% × 12%

    Log-scaled largest reported sample size across curated human studies.

  • Replication33% × 12%

    Independent human studies, capped at three; one study is never treated as replicated.

  • Recency20% × 7%

    Linear decay over a twenty-year window from the most recent curated publication.

  • Source traceability0% × 5%

    Share of curated studies with a verified PMID or DOI in this dataset.

How is this determined? →

Insufficient comparable evidence for quantitative synthesis.

Research timeline

How the evidence accumulated

  1. 2005

    Oat beta-glucan penetration and soothing endpoints in human skin

    Humann = 27 · Journal of Cosmetic Dermatology

  2. 2007

    Colloidal oatmeal: mechanisms and clinical use in dry, itchy skin

    Reviewsample size unavailable · Journal of Drugs in Dermatology (review)

  3. 2010

    Avenanthramides and NF-kB dependent cytokine release in keratinocyte culture

    In-vitrosample size unavailable · Journal of Agricultural and Food Chemistry

Ingredient fingerprint

11 nodes · 13 relationships · seed "avenanthramides"

The fingerprint is a deterministic visual signature: ridge amplitude comes from the number of entities in each tier, node placement from identifier hashes, and opacity from confidence. Two ingredients can never produce the same figure unless their networks are identical.

Open in Biology as Art →

Research

3 curated studies

In-vitroJournal of Agricultural and Food Chemistry · 2010

Avenanthramides and NF-kB dependent cytokine release in keratinocyte culture

Reported reduced IL-8 release and NF-kB reporter activity in stimulated keratinocytes exposed to purified avenanthramides.

Limitations — Purified compounds at defined concentrations, unlike commercial extracts; identifier not verified during curation.

Identifier not curated — search Europe PMCAvenanthramides (colloidal oat)
ReviewJournal of Drugs in Dermatology (review) · 2007

Colloidal oatmeal: mechanisms and clinical use in dry, itchy skin

Summarises reported anti-inflammatory activity of avenanthramides alongside the occlusive and buffering effects of the whole extract.

Limitations — Review; extract composition is variable between products; identifier not verified during curation.

Identifier not curated — search Europe PMCAvenanthramides (colloidal oat)
HumanJournal of Cosmetic Dermatology · 2005n = 27

Oat beta-glucan penetration and soothing endpoints in human skin

Reported improvement in dryness and itch scores, with penetration of the polysaccharide into the upper epidermis described in accompanying imaging.

Limitations — Small sample, manufacturer-supported; identifier not verified during curation.

Identifier not curated — search Europe PMCBeta-glucan · Avenanthramides (colloidal oat)

Community evidence

Submitted by readers

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Reader submissions appear here only after review. They are not part of the curated dataset and do not affect the Skinceptor Evidence Index.

No approved community submissions yet.

Sources

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