Ingredient intelligence
Panthenol
Skin barrier · Panthenol · C9H19NO4
Panthenol is the alcohol analogue of pantothenic acid and a of coenzyme A. It is studied for barrier and irritation .
Any underlined term can be tapped for an everyday-English translation.
Molecular identity
- Formula
- C9H19NO4
- Molecular weight
- 205.25 g/mol
- PubChem CID
- 6015
- ChEBI
- CHEBI:29073
Biological targets
Pantothenate kinase 1 (PANK1)
medium confidencetargets · enzyme
UniProt Q8TE04
How could this ingredient interact with biology?
Biological network
Ingredient → molecule → target → gene/protein → pathway → process → studied outcome. Relationship strength is drawn from the curated confidence tier; nothing is added to make the chain look complete.
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1 lower-confidence relationship is hidden at this filter level. Use “Show more biology” to include them.
Text alternative for this network
- Panthenol is molecule D-Panthenol — high confidence
- Panthenol is molecule Pantothenic acid — high confidence
- D-Panthenol targets Pantothenate kinase 1 (PANK1) — medium confidence
- Pantothenate kinase 1 (PANK1) encoded by PANK1 — medium confidence
- PANK1 participates in Coenzyme A biosynthesis — medium confidence
- Coenzyme A biosynthesis associated with Epidermal barrier formation — medium confidence
- Coenzyme A biosynthesis associated with Cellular energy metabolism — high confidence
- Epidermal barrier formation studied in Studied for barrier recovery and soothing endpoints — medium confidence
- Cellular energy metabolism studied in Studied for barrier recovery and soothing endpoints — medium confidence
Biological pathways
Coenzyme A biosynthesis
high confidencePantothenate is the committed of coenzyme A.
Reactome R-HSA-196783
Evidence engine
Strong
Multiple independent human studies point in the same direction.
Skinceptor Evidence Index
74
experimental · of 100
This index is a research-navigation aid describing how much evidence exists and how it was produced. It is not a medical safety score, an efficacy guarantee, or a clinical recommendation.
Study composition
- Human2
- Randomised controlled trial1
- Total studies
- 3
- Human studies
- 3
- Largest sample
- 33
- Range
- 2002–2016
Index breakdown
- Study design quality77% × 28%
Mean design weight across curated studies (meta-analysis 1.0, RCT 0.9, other human 0.7, review 0.45, animal 0.35, in-vitro 0.25).
- Human evidence share100% × 22%
Proportion of curated evidence measured in people rather than cells or animals.
- Evidence volume63% × 14%
Log-scaled count of curated studies, so volume alone cannot dominate the score.
- Largest sample size51% × 12%
Log-scaled largest reported sample size across curated human studies.
- Replication100% × 12%
Independent human studies, capped at three; one study is never treated as replicated.
- Recency50% × 7%
Linear decay over a twenty-year window from the most recent curated publication.
- Source traceability0% × 5%
Share of curated studies with a verified PMID or DOI in this dataset.
Insufficient comparable evidence for quantitative synthesis.
Research timeline
How the evidence accumulated
2002
Dexpanthenol and epidermal barrier repair after experimental irritation
Randomised controlled trialn = 25 · Contact Dermatitis
2002
Dexpanthenol and epidermal barrier repair after experimental irritation
Humann = 25 · Skin Pharmacology and Applied Skin Physiology
2016
Allantoin in barrier-support formulations: tolerability and hydration endpoints
Humann = 33 · Journal of Cosmetic Dermatology
Ingredient fingerprint
10 nodes · 11 relationships · seed "panthenol"
The fingerprint is a deterministic visual signature: ridge amplitude comes from the number of entities in each tier, node placement from identifier hashes, and opacity from confidence. Two ingredients can never produce the same figure unless their networks are identical.
Open in Biology as Art →Research
3 curated studies
Allantoin in barrier-support formulations: tolerability and hydration endpoints
Reported improved hydration and reduced roughness with an allantoin-containing emollient, without isolating the ingredient.
Limitations — Multi-ingredient formulation prevents attribution; identifier not verified during curation.
Dexpanthenol and epidermal barrier repair after experimental irritation
Reported faster barrier recovery measured by transepidermal water loss compared with vehicle after sodium lauryl sulfate challenge.
Limitations — Experimental irritation model; identifier not verified during curation.
Dexpanthenol and epidermal barrier repair after experimental irritation
Reported faster recovery of transepidermal water loss after sodium lauryl sulfate irritation with dexpanthenol versus vehicle.
Limitations — Experimental irritation model rather than clinical disease; identifier not verified during curation.
Community evidence
Submitted by readers
Reader submissions appear here only after review. They are not part of the curated dataset and do not affect the Skinceptor Evidence Index.
No approved community submissions yet.
Sources
- PubChem 6015Verified 2026-09-14
- Reactome R-HSA-196783Verified 2026-09-14
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