Ingredient intelligence
Acetyl hexapeptide-8
Peptide · Acetyl Hexapeptide-8 · C34H60N14O12S
Acetyl hexapeptide-8 is a synthetic peptide modelled on a SNAP-25 sequence and studied for neuromuscular-signalling endpoints in vitro.
Molecular identity
- Formula
- C34H60N14O12S
- Molecular weight
- 888.99 g/mol
- PubChem CID
- 9862105
- ChEBI
- Data unavailable
Biological targets
Synaptosomal-associated protein 25 (SNAP25)
low confidencemodulates · structural protein
Mechanism described in cell-free and cell models; cutaneous relevance unresolved.
UniProt P60880
How could this ingredient interact with biology?
Biological network
Ingredient → molecule → target → gene/protein → pathway → process → studied outcome. Relationship strength is drawn from the curated confidence tier; nothing is added to make the chain look complete.
drag to pan · hover to isolate a path · click a node for detail
5 lower-confidence relationships are hidden at this filter level. Use “Show more biology” to include them.
Text alternative for this network
- Acetyl hexapeptide-8 is molecule Acetyl hexapeptide-8 — high confidence
Biological pathways
Neurotransmitter release cycle
low confidenceSNARE-complex assembly step targeted in vitro.
Reactome R-HSA-112310
Evidence engine
Insufficient
Not enough curated evidence to characterise this ingredient.
Skinceptor Evidence Index
11
experimental · of 100
This index is a research-navigation aid describing how much evidence exists and how it was produced. It is not a medical safety score, an efficacy guarantee, or a clinical recommendation.
Study composition
- In-vitro1
- Total studies
- 1
- Human studies
- 0
- Largest sample
- Data unavailable
- Range
- 2002–2002
Index breakdown
- Study design quality25% × 28%
Mean design weight across curated studies (meta-analysis 1.0, RCT 0.9, other human 0.7, review 0.45, animal 0.35, in-vitro 0.25).
- Human evidence share0% × 22%
Proportion of curated evidence measured in people rather than cells or animals.
- Evidence volume32% × 14%
Log-scaled count of curated studies, so volume alone cannot dominate the score.
- Largest sample size0% × 12%
Log-scaled largest reported sample size across curated human studies.
- Replication0% × 12%
Independent human studies, capped at three; one study is never treated as replicated.
- Recency0% × 7%
Linear decay over a twenty-year window from the most recent curated publication.
- Source traceability0% × 5%
Share of curated studies with a verified PMID or DOI in this dataset.
Insufficient comparable evidence for quantitative synthesis.
Research timeline
How the evidence accumulated
2002
Acetyl hexapeptide-8 and SNARE complex assembly in vitro
In-vitrosample size unavailable · International Journal of Cosmetic Science
Ingredient fingerprint
7 nodes · 6 relationships · seed "acetyl-hexapeptide-8"
The fingerprint is a deterministic visual signature: ridge amplitude comes from the number of entities in each tier, node placement from identifier hashes, and opacity from confidence. Two ingredients can never produce the same figure unless their networks are identical.
Open in Biology as Art →Research
1 curated study
Acetyl hexapeptide-8 and SNARE complex assembly in vitro
Reported interference with SNAP-25 dependent complex formation in a cell-free system.
Limitations — Cell-free system; cutaneous penetration to neuromuscular junctions not demonstrated.
Community evidence
Submitted by readers
Reader submissions appear here only after review. They are not part of the curated dataset and do not affect the Skinceptor Evidence Index.
No approved community submissions yet.
Sources
- PubChem 9862105retrieved 2026-09-14
Related biology maps