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Ingredient intelligence

Ascorbyl glucoside

Antioxidant · Ascorbyl Glucoside · C12H20O11

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Ascorbyl glucoside is a glycosylated vitamin C derivative. It is more stable than L-ascorbic acid but must be cleaved by glucosidase activity to release ascorbate, and how efficiently that happens in human skin is not well quantified.

Mechanistic only2 curated studies, none measured in people.

Molecular identity

Two-dimensional chemical structure of Ascorbyl glucoside
Formula
C12H20O11
Molecular weight
340.28 g/mol
PubChem CID
54693473
ChEBI
Data unavailable
Open PubChem record →

Biological targets

  • Alpha-glucosidase activity (cutaneous)

    medium confidence

    targets · enzyme

    Required for conversion; the specific cutaneous isoform responsible is not firmly established — data unavailable.

  • Prolyl 4-hydroxylase subunit alpha-1 (P4HA1)

    low confidence

    activates · enzyme

    Ascorbate-dependent cofactor role, inferred from L-ascorbic acid biology.

    UniProt P13674

  • Tyrosinase (TYR)

    low confidence

    inhibits · enzyme

    UniProt P14679

Molecules & genes

Molecules

  • Ascorbyl glucosideC12H20O11 · 340.28 g/mol
  • L-ascorbic acidC6H8O6 · 176.12 g/mol

Genes / proteins

How could this ingredient interact with biology?

Biological network

Ingredient → molecule → target → gene/protein → pathway → process → studied outcome. Relationship strength is drawn from the curated confidence tier; nothing is added to make the chain look complete.

100%
Ascorbyl glucosideAscorbyl glucosideL-ascorbic acidAlpha-glucosidase activit…

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IngredientMoleculeTargetGenePathwayProcessOutcome

11 lower-confidence relationships are hidden at this filter level. Use “Show more biology” to include them.

Text alternative for this network
  • Ascorbyl glucoside is molecule Ascorbyl glucoside — high confidence
  • Ascorbyl glucoside is molecule L-ascorbic acid — high confidence
  • Ascorbyl glucoside targets Alpha-glucosidase activity (cutaneous) — medium confidence

Biological pathways

Collagen biosynthesis and modifying enzymes

low confidence

Ascorbate released from the glucoside can serve as cofactor for collagen prolyl hydroxylases.

Reactome R-HSA-1650814

Melanin biosynthesis

low confidence

Pigment endpoints reported for vitamin C derivatives, with limited derivative-specific data.

Gene Ontology GO:0042438

Evidence engine

Insufficient

Not enough curated evidence to characterise this ingredient.

Skinceptor Evidence Index

22

experimental · of 100

This index is a research-navigation aid describing how much evidence exists and how it was produced. It is not a medical safety score, an efficacy guarantee, or a clinical recommendation.

Study composition

  • In-vitro1
  • Review1
Total studies
2
Human studies
0
Largest sample
Data unavailable
Range
2007–2020

Index breakdown

  • Study design quality35% × 28%

    Mean design weight across curated studies (meta-analysis 1.0, RCT 0.9, other human 0.7, review 0.45, animal 0.35, in-vitro 0.25).

  • Human evidence share0% × 22%

    Proportion of curated evidence measured in people rather than cells or animals.

  • Evidence volume50% × 14%

    Log-scaled count of curated studies, so volume alone cannot dominate the score.

  • Largest sample size0% × 12%

    Log-scaled largest reported sample size across curated human studies.

  • Replication0% × 12%

    Independent human studies, capped at three; one study is never treated as replicated.

  • Recency70% × 7%

    Linear decay over a twenty-year window from the most recent curated publication.

  • Source traceability0% × 5%

    Share of curated studies with a verified PMID or DOI in this dataset.

How is this determined? →

Insufficient comparable evidence for quantitative synthesis.

Research timeline

How the evidence accumulated

  1. 2007

    Ascorbyl glucoside stability and enzymatic release of ascorbic acid in skin models

    In-vitrosample size unavailable · International Journal of Cosmetic Science

  2. 2020

    Vitamin C derivatives for facial hyperpigmentation: a narrative review

    Reviewsample size unavailable · Journal of Cosmetic Dermatology (review)

Ingredient fingerprint

15 nodes · 22 relationships · seed "ascorbyl-glucoside"

The fingerprint is a deterministic visual signature: ridge amplitude comes from the number of entities in each tier, node placement from identifier hashes, and opacity from confidence. Two ingredients can never produce the same figure unless their networks are identical.

Open in Biology as Art →

Research

2 curated studies

ReviewJournal of Cosmetic Dermatology (review) · 2020

Vitamin C derivatives for facial hyperpigmentation: a narrative review

Concludes that derivative-specific human evidence is thinner than for L-ascorbic acid, with conversion efficiency the main open question.

Limitations — Review of heterogeneous small studies; identifier not verified during curation.

Identifier not curated — search Europe PMCAscorbyl glucoside · Magnesium ascorbyl phosphate · L-Ascorbic acid
In-vitroInternational Journal of Cosmetic Science · 2007

Ascorbyl glucoside stability and enzymatic release of ascorbic acid in skin models

Reported greater aqueous stability than L-ascorbic acid and glucosidase-dependent release of free ascorbate in skin homogenates.

Limitations — Homogenate model may overstate in-vivo conversion; identifier not verified during curation.

Identifier not curated — search Europe PMCAscorbyl glucoside · L-Ascorbic acid

Community evidence

Submitted by readers

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Reader submissions appear here only after review. They are not part of the curated dataset and do not affect the Skinceptor Evidence Index.

No approved community submissions yet.

Sources

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