Ingredient intelligence
Coenzyme Q10
Antioxidant · Ubiquinone · C59H90O4
Coenzyme Q10 is a lipid-soluble electron carrier of the mitochondrial respiratory chain and a membrane antioxidant.
Molecular identity
- Formula
- C59H90O4
- Molecular weight
- 863.3 g/mol
- PubChem CID
- 5281915
- ChEBI
- CHEBI:46245
Biological targets
NADH:ubiquinone oxidoreductase core subunit (NDUFS1)
high confidencetargets · complex
UniProt P28331
How could this ingredient interact with biology?
Biological network
Ingredient → molecule → target → gene/protein → pathway → process → studied outcome. Relationship strength is drawn from the curated confidence tier; nothing is added to make the chain look complete.
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1 lower-confidence relationship is hidden at this filter level. Use “Show more biology” to include them.
Text alternative for this network
- Coenzyme Q10 is molecule Ubiquinone-10 — high confidence
- Ubiquinone-10 targets NADH:ubiquinone oxidoreductase core subunit (NDUFS1) — high confidence
- NADH:ubiquinone oxidoreductase core subunit (NDUFS1) encoded by NDUFS1 — high confidence
- NDUFS1 participates in Respiratory electron transport — high confidence
- COQ2 participates in Respiratory electron transport — medium confidence
- NDUFS1 participates in Detoxification of reactive oxygen species — medium confidence
- COQ2 participates in Detoxification of reactive oxygen species — medium confidence
- Respiratory electron transport associated with Cellular energy metabolism — high confidence
- Detoxification of reactive oxygen species associated with Cellular energy metabolism — medium confidence
- Respiratory electron transport associated with Oxidative stress response — medium confidence
- Detoxification of reactive oxygen species associated with Oxidative stress response — medium confidence
Biological pathways
Respiratory electron transport
high confidenceElectron shuttling between complexes I/II and III.
Reactome R-HSA-611105
Detoxification of reactive oxygen species
medium confidenceMembrane antioxidant role.
Reactome R-HSA-3299685
Evidence engine
Insufficient
Not enough curated evidence to characterise this ingredient.
Skinceptor Evidence Index
11
experimental · of 100
This index is a research-navigation aid describing how much evidence exists and how it was produced. It is not a medical safety score, an efficacy guarantee, or a clinical recommendation.
Study composition
- In-vitro1
- Total studies
- 1
- Human studies
- 0
- Largest sample
- Data unavailable
- Range
- 1999–1999
Index breakdown
- Study design quality25% × 28%
Mean design weight across curated studies (meta-analysis 1.0, RCT 0.9, other human 0.7, review 0.45, animal 0.35, in-vitro 0.25).
- Human evidence share0% × 22%
Proportion of curated evidence measured in people rather than cells or animals.
- Evidence volume32% × 14%
Log-scaled count of curated studies, so volume alone cannot dominate the score.
- Largest sample size0% × 12%
Log-scaled largest reported sample size across curated human studies.
- Replication0% × 12%
Independent human studies, capped at three; one study is never treated as replicated.
- Recency0% × 7%
Linear decay over a twenty-year window from the most recent curated publication.
- Source traceability0% × 5%
Share of curated studies with a verified PMID or DOI in this dataset.
Insufficient comparable evidence for quantitative synthesis.
Research timeline
How the evidence accumulated
1999
Coenzyme Q10 in the epidermis: distribution and antioxidant function
In-vitrosample size unavailable · Free Radical Biology and Medicine
Ingredient fingerprint
10 nodes · 14 relationships · seed "coenzyme-q10"
The fingerprint is a deterministic visual signature: ridge amplitude comes from the number of entities in each tier, node placement from identifier hashes, and opacity from confidence. Two ingredients can never produce the same figure unless their networks are identical.
Open in Biology as Art →Research
1 curated study
Coenzyme Q10 in the epidermis: distribution and antioxidant function
Reported measurable CoQ10 in epidermal layers and reduced oxidation markers after supplementation in vitro.
Limitations — In-vitro; identifier not verified during curation.
Community evidence
Submitted by readers
Reader submissions appear here only after review. They are not part of the curated dataset and do not affect the Skinceptor Evidence Index.
No approved community submissions yet.
Sources
- PubChem 5281915retrieved 2026-09-14
- Reactome R-HSA-611105retrieved 2026-09-14
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