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Ingredient intelligence

Epigallocatechin gallate

Antioxidant · Epigallocatechin Gallate · C22H18O11

CompareExplore biology

EGCG is the major green tea catechin, studied for and UV-response biology mainly in cell and animal models.

Single human studyOne curated human study — the finding has not been independently repeated in this dataset.

Any underlined term can be tapped for an everyday-English translation.

Molecular identity

Two-dimensional chemical structure of Epigallocatechin gallate
Formula
C22H18O11
Molecular weight
458.4 g/mol
PubChem CID
65064
ChEBI
CHEBI:4806
Open PubChem record →

Biological targets

  • Matrix metallopeptidase 9 (MMP9)

    low confidence

    inhibits · enzyme

    UniProt P14780

  • NF-E2-related factor 2 (NFE2L2)

    low confidence

    activates · receptor

    UniProt Q16236

Molecules & genes

Molecules

  • Epigallocatechin gallateC22H18O11 · 458.4 g/mol

Genes / proteins

How could this ingredient interact with biology?

Biological network

Ingredient → molecule → target → gene/protein → pathway → process → studied outcome. Relationship strength is drawn from the curated confidence tier; nothing is added to make the chain look complete.

100%
Epigallocatechin gallateEpigallocatechin gallate

drag to pan · hover to isolate a path · click a node for detail

IngredientMoleculeTargetGenePathwayProcessOutcome

8 lower-confidence relationships are hidden at this filter level. Use “Show more biology” to include them.

Text alternative for this network
  • Epigallocatechin gallate is molecule Epigallocatechin gallate — high confidence

Biological pathways

KEAP1-NFE2L2 antioxidant response

low confidence

response element in cell models.

Reactome R-HSA-9755511

Degradation of the extracellular matrix

low confidence

reported .

Reactome R-HSA-1474228

Evidence engine

Limited

Mostly mechanistic, animal or single-study evidence.

Skinceptor Evidence Index

38

experimental · of 100

This index is a research-navigation aid describing how much evidence exists and how it was produced. It is not a medical safety score, an efficacy guarantee, or a clinical recommendation.

Study composition

  • Human1
  • In-vitro1
Total studies
2
Human studies
1
Largest sample
16
Range
2007–2011

Index breakdown

  • Study design quality48% × 28%

    Mean design weight across curated studies (meta-analysis 1.0, RCT 0.9, other human 0.7, review 0.45, animal 0.35, in-vitro 0.25).

  • Human evidence share33% × 22%

    Proportion of curated evidence measured in people rather than cells or animals.

  • Evidence volume50% × 14%

    Log-scaled count of curated studies, so volume alone cannot dominate the score.

  • Largest sample size40% × 12%

    Log-scaled largest reported sample size across curated human studies.

  • Replication33% × 12%

    Independent human studies, capped at three; one study is never treated as replicated.

  • Recency25% × 7%

    Linear decay over a twenty-year window from the most recent curated publication.

  • Source traceability0% × 5%

    Share of curated studies with a verified PMID or DOI in this dataset.

How is this determined? →

Insufficient comparable evidence for quantitative synthesis.

Research timeline

How the evidence accumulated

  1. 2007

    Green tea polyphenols and UV-induced inflammatory markers in human skin

    Humann = 16 · Photodermatology, Photoimmunology and Photomedicine

  2. 2011

    Green tea polyphenols and UV-induced matrix metalloproteinase expression in human skin models

    In-vitrosample size unavailable · Photochemistry and Photobiology

Ingredient fingerprint

10 nodes · 12 relationships · seed "epigallocatechin-gallate"

The fingerprint is a deterministic visual signature: ridge amplitude comes from the number of entities in each tier, node placement from identifier hashes, and opacity from confidence. Two ingredients can never produce the same figure unless their networks are identical.

Open in Biology as Art →

Research

2 curated studies

In-vitroPhotochemistry and Photobiology · 2011

Green tea polyphenols and UV-induced matrix metalloproteinase expression in human skin models

Reported reduced UV-induced MMP-9 expression in treated skin equivalents.

Limitations — Skin equivalent model; identifier not verified; human endpoints lacking.

Identifier not curated — search Europe PMCEpigallocatechin gallate
HumanPhotodermatology, Photoimmunology and Photomedicine · 2007n = 16

Green tea polyphenols and UV-induced inflammatory markers in human skin

Reported reduced UV-induced erythema and inflammatory infiltrate markers in biopsies from polyphenol-treated sites.

Limitations — Small, short-duration, single-centre; identifier not verified during curation.

Identifier not curated — search Europe PMCEpigallocatechin gallate

Community evidence

Submitted by readers

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Reader submissions appear here only after review. They are not part of the curated dataset and do not affect the Skinceptor Evidence Index.

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Sources

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