Ingredient intelligence
Madecassoside
Botanical · Madecassoside · C48H78O20
Madecassoside is a Centella asiatica saponin studied for antioxidant and matrix-related endpoints in cell and animal models.
Molecular identity
- Formula
- C48H78O20
- Molecular weight
- 975.1 g/mol
- PubChem CID
- 131801722
- ChEBI
- Data unavailable
Biological targets
Matrix metallopeptidase 1 (MMP1)
low confidenceinhibits · enzyme
UniProt P03956
How could this ingredient interact with biology?
Biological network
Ingredient → molecule → target → gene/protein → pathway → process → studied outcome. Relationship strength is drawn from the curated confidence tier; nothing is added to make the chain look complete.
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6 lower-confidence relationships are hidden at this filter level. Use “Show more biology” to include them.
Text alternative for this network
- Madecassoside is molecule Madecassoside — high confidence
Biological pathways
Degradation of the extracellular matrix
low confidenceMMP expression changes reported in UV-exposed skin models.
Reactome R-HSA-1474228
Evidence engine
Insufficient
Not enough curated evidence to characterise this ingredient.
Skinceptor Evidence Index
16
experimental · of 100
This index is a research-navigation aid describing how much evidence exists and how it was produced. It is not a medical safety score, an efficacy guarantee, or a clinical recommendation.
Study composition
- Animal1
- Total studies
- 1
- Human studies
- 0
- Largest sample
- Data unavailable
- Range
- 2010–2010
Index breakdown
- Study design quality35% × 28%
Mean design weight across curated studies (meta-analysis 1.0, RCT 0.9, other human 0.7, review 0.45, animal 0.35, in-vitro 0.25).
- Human evidence share0% × 22%
Proportion of curated evidence measured in people rather than cells or animals.
- Evidence volume32% × 14%
Log-scaled count of curated studies, so volume alone cannot dominate the score.
- Largest sample size0% × 12%
Log-scaled largest reported sample size across curated human studies.
- Replication0% × 12%
Independent human studies, capped at three; one study is never treated as replicated.
- Recency20% × 7%
Linear decay over a twenty-year window from the most recent curated publication.
- Source traceability0% × 5%
Share of curated studies with a verified PMID or DOI in this dataset.
Insufficient comparable evidence for quantitative synthesis.
Research timeline
How the evidence accumulated
2010
Centella asiatica triterpenes and wound-related collagen deposition
Animalsample size unavailable · Journal of Ethnopharmacology
Ingredient fingerprint
8 nodes · 8 relationships · seed "madecassoside"
The fingerprint is a deterministic visual signature: ridge amplitude comes from the number of entities in each tier, node placement from identifier hashes, and opacity from confidence. Two ingredients can never produce the same figure unless their networks are identical.
Open in Biology as Art →Research
1 curated study
Centella asiatica triterpenes and wound-related collagen deposition
Reported increased collagen deposition and faster wound closure in a rodent model.
Limitations — Animal wound model; not equivalent to intact cosmetic use; identifier not verified.
Community evidence
Submitted by readers
Reader submissions appear here only after review. They are not part of the curated dataset and do not affect the Skinceptor Evidence Index.
No approved community submissions yet.
Sources
- PubChem 131801722retrieved 2026-09-14
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