Ingredient intelligence
Magnesium ascorbyl phosphate
Antioxidant · Magnesium Ascorbyl Phosphate · C6H6MgO9P
A phosphorylated, salt-stabilised vitamin C derivative studied as a more stable alternative to L-ascorbic acid. It requires enzymatic conversion to free ascorbate to act.
Molecular identity
- Formula
- C6H6MgO9P
- Molecular weight
- 289.39 g/mol
- PubChem CID
- 23674863
- ChEBI
- Data unavailable
Biological targets
Alkaline phosphatase (ALPL)
medium confidencetargets · enzyme
Dephosphorylation is required to liberate ascorbate.
UniProt P05186Prolyl 4-hydroxylase subunit alpha-1 (P4HA1)
medium confidenceactivates · enzyme
Indirect, via released ascorbate.
UniProt P13674
How could this ingredient interact with biology?
Biological network
Ingredient → molecule → target → gene/protein → pathway → process → studied outcome. Relationship strength is drawn from the curated confidence tier; nothing is added to make the chain look complete.
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1 lower-confidence relationship is hidden at this filter level. Use “Show more biology” to include them.
Text alternative for this network
- Magnesium ascorbyl phosphate is molecule Magnesium ascorbyl phosphate — high confidence
- Magnesium ascorbyl phosphate targets Alkaline phosphatase (ALPL) — medium confidence
- Magnesium ascorbyl phosphate activates Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) — medium confidence
- Alkaline phosphatase (ALPL) encoded by ALPL — medium confidence
- Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) encoded by P4HA1 — medium confidence
- ALPL participates in Collagen biosynthesis and modifying enzymes — medium confidence
- P4HA1 participates in Collagen biosynthesis and modifying enzymes — medium confidence
- Collagen biosynthesis and modifying enzymes associated with Collagen biosynthesis — medium confidence
Biological pathways
Collagen biosynthesis and modifying enzymes
medium confidenceActs through released ascorbate as a hydroxylase cofactor.
Reactome R-HSA-1650814
Evidence engine
Insufficient
Not enough curated evidence to characterise this ingredient.
Skinceptor Evidence Index
19
experimental · of 100
This index is a research-navigation aid describing how much evidence exists and how it was produced. It is not a medical safety score, an efficacy guarantee, or a clinical recommendation.
Study composition
- In-vitro1
- Review1
- Total studies
- 2
- Human studies
- 0
- Largest sample
- Data unavailable
- Range
- 1991–2012
Index breakdown
- Study design quality35% × 28%
Mean design weight across curated studies (meta-analysis 1.0, RCT 0.9, other human 0.7, review 0.45, animal 0.35, in-vitro 0.25).
- Human evidence share0% × 22%
Proportion of curated evidence measured in people rather than cells or animals.
- Evidence volume50% × 14%
Log-scaled count of curated studies, so volume alone cannot dominate the score.
- Largest sample size0% × 12%
Log-scaled largest reported sample size across curated human studies.
- Replication0% × 12%
Independent human studies, capped at three; one study is never treated as replicated.
- Recency30% × 7%
Linear decay over a twenty-year window from the most recent curated publication.
- Source traceability0% × 5%
Share of curated studies with a verified PMID or DOI in this dataset.
Insufficient comparable evidence for quantitative synthesis.
Research timeline
How the evidence accumulated
1991
Ascorbate requirement for hydroxylation and secretion of procollagen
Reviewsample size unavailable · American Journal of Clinical Nutrition (review)
2012
Stability and skin delivery of ascorbyl phosphate derivatives
In-vitrosample size unavailable · International Journal of Cosmetic Science
Ingredient fingerprint
9 nodes · 9 relationships · seed "magnesium-ascorbyl-phosphate"
The fingerprint is a deterministic visual signature: ridge amplitude comes from the number of entities in each tier, node placement from identifier hashes, and opacity from confidence. Two ingredients can never produce the same figure unless their networks are identical.
Open in Biology as Art →Research
2 curated studies
Stability and skin delivery of ascorbyl phosphate derivatives
Reported improved formulation stability for magnesium ascorbyl phosphate but slower and variable conversion to free ascorbate in skin models.
Limitations — Formulation and ex-vivo delivery only; no clinical endpoints.
Ascorbate requirement for hydroxylation and secretion of procollagen
Establishes ascorbate as an obligatory cofactor for prolyl and lysyl hydroxylases in collagen maturation.
Limitations — Nutritional/biochemical focus rather than topical cosmetic use.
Community evidence
Submitted by readers
Reader submissions appear here only after review. They are not part of the curated dataset and do not affect the Skinceptor Evidence Index.
No approved community submissions yet.
Sources
- PubChem 23674863retrieved 2026-09-14
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