Ingredient intelligence
Palmitoyl pentapeptide-4
Peptide · Palmitoyl Pentapeptide-4 · C46H83N9O11
Palmitoyl pentapeptide-4 is a lipidated fragment of the type I collagen propeptide sequence, studied as a matrix-signalling peptide.
Molecular identity
- Formula
- C46H83N9O11
- Molecular weight
- 962.2 g/mol
- PubChem CID
- 9862091
- ChEBI
- Data unavailable
Biological targets
Collagen type I alpha 1 chain (COL1A1)
low confidenceassociated with · structural protein
UniProt P02452Fibronectin 1 (FN1)
low confidenceassociated with · structural protein
UniProt P02751
How could this ingredient interact with biology?
Biological network
Ingredient → molecule → target → gene/protein → pathway → process → studied outcome. Relationship strength is drawn from the curated confidence tier; nothing is added to make the chain look complete.
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7 lower-confidence relationships are hidden at this filter level. Use “Show more biology” to include them.
Text alternative for this network
- Palmitoyl pentapeptide-4 is molecule Pal-KTTKS — high confidence
Biological pathways
Collagen biosynthesis and modifying enzymes
low confidenceProposed feedback signalling on procollagen synthesis.
Reactome R-HSA-1650814
Evidence engine
Limited
Mostly mechanistic, animal or single-study evidence.
Skinceptor Evidence Index
44
experimental · of 100
This index is a research-navigation aid describing how much evidence exists and how it was produced. It is not a medical safety score, an efficacy guarantee, or a clinical recommendation.
Study composition
- Randomised controlled trial1
- In-vitro1
- Total studies
- 2
- Human studies
- 1
- Largest sample
- 62
- Range
- 2005–2013
Index breakdown
- Study design quality57% × 28%
Mean design weight across curated studies (meta-analysis 1.0, RCT 0.9, other human 0.7, review 0.45, animal 0.35, in-vitro 0.25).
- Human evidence share33% × 22%
Proportion of curated evidence measured in people rather than cells or animals.
- Evidence volume50% × 14%
Log-scaled count of curated studies, so volume alone cannot dominate the score.
- Largest sample size60% × 12%
Log-scaled largest reported sample size across curated human studies.
- Replication33% × 12%
Independent human studies, capped at three; one study is never treated as replicated.
- Recency35% × 7%
Linear decay over a twenty-year window from the most recent curated publication.
- Source traceability0% × 5%
Share of curated studies with a verified PMID or DOI in this dataset.
Insufficient comparable evidence for quantitative synthesis.
Research timeline
How the evidence accumulated
2005
Palmitoyl pentapeptide and procollagen synthesis in fibroblast culture
In-vitrosample size unavailable · International Journal of Cosmetic Science
2013
A randomised trial of a pentapeptide-containing moisturiser for periorbital wrinkles
Randomised controlled trialn = 62 · Journal of Cosmetic Dermatology
Ingredient fingerprint
9 nodes · 9 relationships · seed "palmitoyl-pentapeptide-4"
The fingerprint is a deterministic visual signature: ridge amplitude comes from the number of entities in each tier, node placement from identifier hashes, and opacity from confidence. Two ingredients can never produce the same figure unless their networks are identical.
Open in Biology as Art →Research
2 curated studies
A randomised trial of a pentapeptide-containing moisturiser for periorbital wrinkles
Reported small improvements in wrinkle depth versus vehicle, with overlapping confidence intervals on several endpoints.
Limitations — Small effect size; identifier not verified; peptide not isolated from other actives in the formulation.
Palmitoyl pentapeptide and procollagen synthesis in fibroblast culture
Reported increased collagen I and fibronectin expression in treated fibroblast cultures.
Limitations — In-vitro; identifier not verified; no dermal delivery data.
Community evidence
Submitted by readers
Reader submissions appear here only after review. They are not part of the curated dataset and do not affect the Skinceptor Evidence Index.
No approved community submissions yet.
Sources
- PubChem 9862091retrieved 2026-09-14
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