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Ingredient intelligence

Resveratrol

Antioxidant · Resveratrol · C14H12O3

CompareExplore biology

Resveratrol is a plant stilbene studied for sirtuin-related and biology. Most reported skin effects come from cell or animal models.

Mechanistic only3 curated studies, none measured in people.

Any underlined term can be tapped for an everyday-English translation.

Molecular identity

Two-dimensional chemical structure of Resveratrol
Formula
C14H12O3
Molecular weight
228.24 g/mol
PubChem CID
445154
ChEBI
CHEBI:27881
Open PubChem record →

Biological targets

  • Sirtuin 1 (SIRT1)

    medium confidence

    activates · enzyme

    is assay-dependent and debated in the literature.

    UniProt Q96EB6

  • Tyrosinase (TYR)

    low confidence

    inhibits · enzyme

    UniProt P14679

  • NF-kappa-B p65 (RELA)

    low confidence

    inhibits · receptor

    UniProt Q04206

Molecules & genes

Molecules

  • trans-ResveratrolC14H12O3 · 228.24 g/mol

Genes / proteins

How could this ingredient interact with biology?

Biological network

Ingredient → molecule → target → gene/protein → pathway → process → studied outcome. Relationship strength is drawn from the curated confidence tier; nothing is added to make the chain look complete.

100%
Resveratroltrans-ResveratrolSirtuin 1 (SIRT1)SIRT1NAD+ dependent deacetylat…Oxidative stress response

drag to pan · hover to isolate a path · click a node for detail

IngredientMoleculeTargetGenePathwayProcessOutcome

7 lower-confidence relationships are hidden at this filter level. Use “Show more biology” to include them.

Text alternative for this network
  • Resveratrol is molecule trans-Resveratrol — high confidence
  • trans-Resveratrol activates Sirtuin 1 (SIRT1) — medium confidence
  • Sirtuin 1 (SIRT1) encoded by SIRT1 — medium confidence
  • SIRT1 participates in NAD+ dependent deacetylation (sirtuins) — medium confidence
  • NAD+ dependent deacetylation (sirtuins) associated with Oxidative stress response — medium confidence

Biological pathways

NAD+ dependent deacetylation (sirtuins)

medium confidence

Sirtuin-mediated deacetylation of stress-response substrates.

Reactome R-HSA-3247509

Melanin biosynthesis

low confidence

.

Gene Ontology GO:0042438

Evidence engine

Insufficient

Not enough curated evidence to characterise this ingredient.

Skinceptor Evidence Index

22

experimental · of 100

This index is a research-navigation aid describing how much evidence exists and how it was produced. It is not a medical safety score, an efficacy guarantee, or a clinical recommendation.

Study composition

  • In-vitro2
  • Review1
Total studies
3
Human studies
0
Largest sample
Data unavailable
Range
2010–2019

Index breakdown

  • Study design quality32% × 28%

    Mean design weight across curated studies (meta-analysis 1.0, RCT 0.9, other human 0.7, review 0.45, animal 0.35, in-vitro 0.25).

  • Human evidence share0% × 22%

    Proportion of curated evidence measured in people rather than cells or animals.

  • Evidence volume63% × 14%

    Log-scaled count of curated studies, so volume alone cannot dominate the score.

  • Largest sample size0% × 12%

    Log-scaled largest reported sample size across curated human studies.

  • Replication0% × 12%

    Independent human studies, capped at three; one study is never treated as replicated.

  • Recency65% × 7%

    Linear decay over a twenty-year window from the most recent curated publication.

  • Source traceability0% × 5%

    Share of curated studies with a verified PMID or DOI in this dataset.

How is this determined? →

Insufficient comparable evidence for quantitative synthesis.

Research timeline

How the evidence accumulated

  1. 2010

    Resveratrol as a sirtuin activator: assay dependence and interpretation

    In-vitrosample size unavailable · Journal of Biological Chemistry

  2. 2011

    Resveratrol and SIRT1-dependent responses in cultured human dermal fibroblasts

    In-vitrosample size unavailable · Experimental Dermatology

  3. 2019

    Topical resveratrol formulations and photoprotection endpoints: a narrative review

    Reviewsample size unavailable · Journal of Cosmetic Dermatology (review)

Ingredient fingerprint

13 nodes · 19 relationships · seed "resveratrol"

The fingerprint is a deterministic visual signature: ridge amplitude comes from the number of entities in each tier, node placement from identifier hashes, and opacity from confidence. Two ingredients can never produce the same figure unless their networks are identical.

Open in Biology as Art →

Research

3 curated studies

ReviewJournal of Cosmetic Dermatology (review) · 2019

Topical resveratrol formulations and photoprotection endpoints: a narrative review

Concludes that human topical data remain limited and heterogeneous despite consistent antioxidant activity in cell models.

Limitations — Review of small, mostly non-randomised studies; identifier not verified during curation.

Identifier not curated — search Europe PMCResveratrol · Ferulic acid
In-vitroExperimental Dermatology · 2011

Resveratrol and SIRT1-dependent responses in cultured human dermal fibroblasts

Reported SIRT1-associated changes in oxidative-stress markers in fibroblast culture after resveratrol exposure.

Limitations — In-vitro only, supraphysiological concentrations; identifier not verified during curation.

Identifier not curated — search Europe PMCResveratrol
In-vitroJournal of Biological Chemistry · 2010

Resveratrol as a sirtuin activator: assay dependence and interpretation

Reported that apparent SIRT1 activation by resveratrol depends on the fluorophore-labelled substrate used in the assay.

Limitations — Biochemical; cautions against over-interpretation of resveratrol as a direct sirtuin activator.

Identifier not curated — search Europe PMCResveratrol

Community evidence

Submitted by readers

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Reader submissions appear here only after review. They are not part of the curated dataset and do not affect the Skinceptor Evidence Index.

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Sources

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