Ingredient intelligence
Hydroxypinacolone retinoate
Retinoid · Hydroxypinacolone Retinoate · C26H38O3
Hydroxypinacolone retinoate is a retinoic acid ester marketed as a cosmetic retinoid. Public mechanistic data are thinner than for retinol.
Molecular identity
- Formula
- C26H38O3
- Molecular weight
- 398.6 g/mol
- PubChem CID
- 6438292
- ChEBI
- Data unavailable
Biological targets
Retinoic acid receptor gamma (RARG)
low confidenceassociated with · receptor
UniProt P13631
How could this ingredient interact with biology?
Biological network
Ingredient → molecule → target → gene/protein → pathway → process → studied outcome. Relationship strength is drawn from the curated confidence tier; nothing is added to make the chain look complete.
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5 lower-confidence relationships are hidden at this filter level. Use “Show more biology” to include them.
Text alternative for this network
- Hydroxypinacolone retinoate is molecule Hydroxypinacolone retinoate — high confidence
Biological pathways
Signalling by retinoic acid
low confidencePresumed retinoid receptor signalling; independent confirmation limited.
Reactome R-HSA-5362517
Evidence engine
Insufficient
Not enough curated evidence to characterise this ingredient.
Skinceptor Evidence Index
22
experimental · of 100
This index is a research-navigation aid describing how much evidence exists and how it was produced. It is not a medical safety score, an efficacy guarantee, or a clinical recommendation.
Study composition
- Review1
- Total studies
- 1
- Human studies
- 0
- Largest sample
- Data unavailable
- Range
- 2021–2021
Index breakdown
- Study design quality45% × 28%
Mean design weight across curated studies (meta-analysis 1.0, RCT 0.9, other human 0.7, review 0.45, animal 0.35, in-vitro 0.25).
- Human evidence share0% × 22%
Proportion of curated evidence measured in people rather than cells or animals.
- Evidence volume32% × 14%
Log-scaled count of curated studies, so volume alone cannot dominate the score.
- Largest sample size0% × 12%
Log-scaled largest reported sample size across curated human studies.
- Replication0% × 12%
Independent human studies, capped at three; one study is never treated as replicated.
- Recency75% × 7%
Linear decay over a twenty-year window from the most recent curated publication.
- Source traceability0% × 5%
Share of curated studies with a verified PMID or DOI in this dataset.
Insufficient comparable evidence for quantitative synthesis.
Research timeline
How the evidence accumulated
2021
Cosmetic retinoid esters: an assessment of available public evidence
Reviewsample size unavailable · Cosmetics (review)
Ingredient fingerprint
7 nodes · 6 relationships · seed "hydroxypinacolone-retinoate"
The fingerprint is a deterministic visual signature: ridge amplitude comes from the number of entities in each tier, node placement from identifier hashes, and opacity from confidence. Two ingredients can never produce the same figure unless their networks are identical.
Open in Biology as Art →Research
1 curated study
Cosmetic retinoid esters: an assessment of available public evidence
Notes that public independent data on hydroxypinacolone retinoate are limited relative to retinol and retinoic acid.
Limitations — Review highlighting an evidence gap rather than reporting new results.
Community evidence
Submitted by readers
Reader submissions appear here only after review. They are not part of the curated dataset and do not affect the Skinceptor Evidence Index.
No approved community submissions yet.
Sources
- PubChem 6438292retrieved 2026-09-14
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